ABSTRACT
OBJECTIVE: This study was performed to evaluate the clinical characteristics, histopathology and prognosis of endometrial cancer under 40 years of age. METHODS: This retrospective study was based on medical records including pathologic reports of 6 women under the age of 40 with histologically proven endometrial cancer at the Department of Obstetrics and Gynecology, Gyeongsang National University Hospital from Jan. 1991 to Dec. 2002. The survival of patients was determined by description of last follow up date in medical records. If more than 3 months passed from last follow up date, we used phone call to identify the status of patients. RESULTS: The mean age of 6 cases with young endometrial cancer was 36.5 years. The most common symptom was abnormal vaginal bleeding (50%). The parity of the patients was nulliparity in 2 cases (33.3%), primiparity in 2 cases (33.3%) and multiparity in 2 cases (33.3%). The body weight over 61 kg was in 4 cases (66.7%) and obesity was in 3 cases (50%). The risk factors and associated diseases were amenorrhea or irregular menstruation in 2 cases (33.3%), hypertension in 1 case (16.7%) and Cushing syndrome in 1 case (16.7%). Histopathologic subtypes was adenocarcinoma in 3 cases (50%), adenoacanthoma in 1 case (16.7%), papillary adenocarcinoma in 1 case (16.7%) and stromal sarcoma in 1 case (16.7%). The stages of the patients were classified as stage I in 5 cases (83.3%) and stage II in 1 case (16.7%). The grades were classified into grade 1 in 4 cases (66.7%), grade 2 in 1 case ( 16.7%) and grade 3 in 1 case (16.7%). All of the patients were treated by primary surgery, 2 cases were treated by surgery with radiation therapy, 1 case with hormonal therapy, 1 case with chemotherapy. All except one case (gade 3 with <1/2 myometrial invasion) were survived. CONCLUSION: It is concluded that endometrial cancer has a favorable prognosis in the young women than in the older patients because it diagnosed at early stage with lower grade.
Subject(s)
Female , Humans , Adenocarcinoma , Adenocarcinoma, Papillary , Amenorrhea , Body Weight , Cushing Syndrome , Drug Therapy , Endometrial Neoplasms , Follow-Up Studies , Gynecology , Hypertension , Medical Records , Menstruation , Obesity , Obstetrics , Parity , Prognosis , Retrospective Studies , Risk Factors , Sarcoma , Uterine HemorrhageABSTRACT
Intracranial astrocytoma is often discovered in third-fifth decade and occupies about 12% of the intracranial tumor patients. The concurrence of tumors of the brain and pregnancy is uncommon, moreover, astrocytoma of the brain in term pregnancy is very rare. Generally, astrocytoma is divided into six subgroups. Among them anaplastic astrocytoma is thought to be a malignant brain tumor. In the management of patients with brain tumor complicating pregnancy, judgments with regard to the optimal time for neurologic studies and operation and the mode of delivery are frequently difficult and occasionally controversial. We experienced a case of anaplastic astrocytoma of left frontal lobe, which was diagnosed by MR imaging at the third trimester of pregnancy. We report the case with a brief review of literature.
Subject(s)
Female , Humans , Pregnancy , Astrocytoma , Brain , Brain Neoplasms , Frontal Lobe , Judgment , Magnetic Resonance Imaging , Pregnancy Trimester, ThirdABSTRACT
Trisomy 22 is a frequent finding in spontaneous abortion. However, survival to term is tenuous. So far there have been about 85 cases of trisomy 22. Most of all cases, trisomy 22 was result of 3:1 meiotic segregation in the maternal 11;22 translocation carrier. These patients have a supernumerary, abnormal chromosome 22 [der(22)], in their chromosome constitution: 47,XX(or XY),+der(22),t(11q;22q). Affected children have a distinct phenotype with multiple anomalies and severe mental retardation. We now report a viable case of 47,XX,+der(22)t(11;22)(q25;q13.1) resulting from 3:1 segregation in paternal translocation.